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Findings of research misconduct

Notice NOT-OD-20-139 from the NIH Guide for Grants and Contracts
Categories: NIH

Biomarkers of Dietary Intake and Exposure (U2C Clinical Trial Required)

Funding Opportunity RFA-DK-20-005 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement is to invite applications from multidisciplinary teams for the development of metabolomics-based dietary intake biomarkers and validate them against current benchmark dietary biomarkers and dietary assessment approaches.
Categories: NIH

Biomarkers of Dietary Intake and Exposure Coordinating Center (U24 Clinical Trial Not Allowed)

Funding Opportunity RFA-DK-20-007 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites cooperative agreement applications under U24 mechanism for a Data Coordination Center to participate and coordinate in a dietary biomarker development study. A companion FOA (RFA DK-20-005), Biomarkers of Dietary Intake and Exposure (U2C Clinical Trial Required) invites multidisciplinary teams to discover, develop and validate dietary biomarkers of intake of wide range of food groups and food types and evaluate the performance of these markers and compare them with dietary assessment methodologies and other benchmark predictive markers.
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Non-invasive Diagnostics to Improve Gynecologic Health (R43/R44 Clinical Trial Optional)

Funding Opportunity RFA-HD-21-020 from the NIH Guide for Grants and Contracts. The purpose of the Non-invasive Diagnostics in Gynecologic Health RFA is to support SBIR projects to small businesses using advanced technologies (e.g., bio-chips, microfluidics, and mobile technologies) to develop novel or improved diagnostic and/or screening approaches, tools, or devices for endometriosis, adenomyosis, and/or uterine fibroids. The ultimate goal of the program is to improve human gynecologic health by fostering partnerships between small businesses and experts in diverse fields of research to commercialize approaches that improve accuracy and decrease the delay in diagnosis and/or screening of the named gynecologic conditions. These projects will also encourage collaborations with investigators and small businesses who have not yet applied their expertise to gynecologic research, thereby expanding the potential scientific insight and investigational toolkit available to these projects. It is anticipated that, through rigorous collaborative R and D efforts, safe and effective techniques, instruments, and devices can be developed for use in the evaluation and diagnosis of women with endometriosis, uterine fibroids, or adenomyosis. Within the disorders noted above, projects that address a specific and well-characterized clinical need will be considered of high potential impact. The technologies developed with funding through this FOA are expected to be integrated systems or, if they are novel components, to be easily integrated into existing systems. Some other technical features that are expected are the following: reliability, robustness, safety, simplicity, reliance on the appropriate baseline information, contextual awareness, and inclusion of software to support decision-making where appropriate. Proposed tools and technologies should incorporate existing standards and consider regulatory requirements where appropriate. In addition, improved access to underserved areas, and cost-effectiveness should be highlighted.
Categories: NIH

Aging, Cancer-Initiating Cells, and Cancer Development (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-CA-20-040 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) and National Institute on Aging (NIA) will promote research to advance the understanding of the mechanistic factors and cellular interactions during aging that contributes to cancer initiation. Collaborations are strongly encouraged between scientists in the fields of aging biology and cancer biology. Applications should address key questions regarding how hallmarks of aging that lead to impaired cellular activities (metabolic alterations, proteostasis, epigenetic changes, and DNA repair) and alterations in the microenvironment (inflammation and immunosenescence) contribute to the development and outgrowth of cancer-initiating cells.
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Continuation of the Human Pancreas Analysis Program (HPAP) for Type 1 Diabetes (HPAP-T1D) (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-DK-20-016 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites a cooperative agreement application to continue the mission of the existing Human Pancreas Analysis Program (HPAP). This FOA will support one team of investigators with combined expertise in human pancreas physiology and pathophysiology; collection, processing and multimodal analysis of human pancreatic tissues; and biological database building, curation and management, that will be tasked to: 1) identify, collect and intensively characterize primary pancreatic tissues from patients with type 1 diabetes (T1D) or at risk of developing the disease, as well as age-matched controls; and 2) analyze, organize and share the data resulting from the study of these tissues through the existing PANC DB open-access resource database. HPAP is a component of the Human Islet Research Network or HIRN. HIRN was created in 2014 to support innovative and collaborative translational research to understand how human beta cells are lost in T1D, and to find innovative strategies to protect and replace functional human beta cell mass.
Categories: NIH

NIH ACTIV vaccine working group weighs role of human challenge studies for SARS-CoV-2 vaccine development

NIH News Releases - July 1, 2020 - 9:00pm
The authors conclude that large, randomized, controlled trials of SARS-CoV-2 are the fastest and most effective path forward for establishing vaccine safety and efficacy.

Categories: NIH

NIH taps Dr. Shannon Zenk as director of the National Institute of Nursing Research

NIH News Releases - July 1, 2020 - 3:30pm
She is expected to begin her new role as the NINR director in September.

Categories: NIH

Complexity of human tooth enamel revealed at atomic level in NIH-funded study

NIH News Releases - July 1, 2020 - 3:00pm
Unprecedented details of enamel structure may point to new ways to prevent or halt cavities.

Categories: NIH

Network of the National Library of Medicine Evaluation Center (U24) (Clinical Trial Not Allowed)

Funding Opportunity RFA-LM-20-002 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites cooperative agreement (U24) applications for organizations to serve as the Evaluation Center for the Network of the National Library of Medicine (NNLM). The goal of the NNLM is to advance the progress of medicine, improve public health by providing U.S. health professionals and the public with equal access to biomedical data and information, and improve individual's access to information to enable them to make informed decisions about their health. The NNLM works through libraries and other member organizations to support a workforce for biomedical and health information resources and data, improve health literacy, and increase health equity. Seven health sciences libraries function as the Regional Medical Library (RML) for their respective region. The RMLs work together to coordinate a network of member libraries and other organizations to carry out local, regional and national programs. These Network members develop collaborations with other organizations to improve access to biomedical information resources throughout the nation. The NNLM program is coordinated by the NLM Office of Engagement and Training. The NNLM Evaluation Center (NEC) will coordinate the assessment of the impact, efficacy and value of NNLM activities, services, and resources. A special focus will be placed on assessing community engagement and measuring its impact on persons who experience health disparities, and populations underrepresented in biomedical research. The NECs activities will include, among others, developing evaluation tools, planning studies, providing evaluation training to the RMLs, Offices, Centers, and sub-awardees of the NNLM, and assessing the effectiveness of national initiatives and selected programs. The NEC will provide NNLM with essential information for developing, maintaining, and evolving effective health information engagement and outreach activities for diverse populations.
Categories: NIH

NIDA Mentored Clinical Scientist Development Program Award in Substance Use and Substance Use Disorder Research (K12 Clinical Trial Optional)

Funding Opportunity PAR-20-249 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages applications for institutional research career development (K12) programs that propose to support intensive supervised research training and career development experiences for clinician scientists (Scholars) leading to research independence in the area of substance use and substance use disorder research.
Categories: NIH
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