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Penn Today highlights a new study published in the journal Cell co-authored by research associate Sarah Tishkoff which sequenced the genomes of 180 individuals from 12 African indigenous groups and performed a rigorous whole-genome analysis of such a genetically diverse mix of African populations. The results shed light on the origin of modern humans, African population history, and local adaptation.
Image: Tishkoff Laboratory
"Genomic study of indigenous Africans paints complex picture of human origins and local adaptation," Katherine Unger Baillie, Penn Today, March 2, 2023.
Spence JA, Tishkoff SA, et al. "Whole-genome sequencing reveals a complex African population demographic history and signatures of local adaptation" Cell, Volume 186, Issue 5, 8 March 2023,.
Sarah Tishkoff and Collaborators were in the news after having received a $2.7 million grant by the Chan Zuckerberg Initiative to study gene expression and epigenetic variation in African immigrant populations in Philadelphia, Detroit, and Belgium, as well as populations from Morocco and Tanzania to increase understanding of the various risks of multiple diseases.
Sarah A.Tishkoff (PARC Research Associate) and Madylyn Ritchie have been elected as new members to the National Academy of Medicine, one of the highest honors in the field of health and medicine. Her election to the NAM recognizes her as a "pioneer of African evolutionary genomics research". Read more in the Penn Medicine Announcement and in Penn Today
David and Lyn Silfen University Professor of Genetics and Biology
Ph.D., Genetics, Yale University, 1996