Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

TitlePlasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging
Publication TypeJournal Article
Year of Publication2016
AuthorsAbner, Erin L., Gregory A. Jicha, Leslie M. Shaw, John Q. Trojanowski, and Edward J. Goetzl
JournalAnnals of Clinical and Translational Neurology
Volume3
Pagination399-403
ISBN Number2328-9503
Accession NumberPMID: 27231710
AbstractPlasma neuronal exosomal levels of pathogenic Alzheimer's disease (AD) proteins, cellular survival factors, and lysosomal proteins distinguish AD patients from control subjects, but changes in these exosomal proteins associated with normal aging have not been described for cognitively intact subjects. Plasma neuronal exosomal levels of P-T181-tau, P-S396-tau, Aβ1-42, cathepsin D, repressor element 1-silencing transcription factor, and neurogranin were quantified longitudinally in cognitively intact older adults using two samples collected at 3- to 11-year intervals. Except for P-S396-tau, exosomal protein levels changed significantly with aging, but were largely outside the range observed in AD patients.
URLhttp://dx.doi.org/10.1002/acn3.309
PMCIDPMCID: PMC4863753