While effective treatments for major depression are available, there is still room for improvement. This special Research in Context feature explores the development of more effective ways to treat depression, including personalized treatment approaches and both old and new drugs.

Researchers developed a wireless implantable device that can monitor bladder filling and emptying in real time and send data to a smartphone.

Researchers found that depleting certain stem cells improved the immune systems of aged mice.

Researchers pinpointed gut bacteria that affect levels of cholesterol and other compounds linked to heart disease.

A study showed that a simple skin biopsy could identify people who had Parkinson’s disease or similar disorders with a high degree of accuracy.

Scientists identified a specific subtype of bacteria implicated in gum disease that may promote the growth of colorectal tumors.

Researchers found that SARS-CoV-2 can damage heart tissue without directly infecting it.

Bariatric surgery helped people with type 2 diabetes better control their blood glucose years later compared to medical and lifestyle interventions.

Researchers identified a brain circuit that controls vocalization and prevents it from interfering with breathing in mice.

Youth with ADHD have elevated brain activity connecting the frontal cortex with the information processing centers deep in the brain.

Researchers designed a synthetic drug that shuts down protein production in a range of different bacteria.

Findings about a metabolite of niacin, or vitamin B3, raise concerns about the health effects of too much niacin and suggest new measures to help prevent or treat cardiovascular disease

An intervention given to pregnant women by non-specialist providers greatly reduced the chances of developing postpartum depression or anxiety.

Researchers compared people with post-infectious ME/CFS to those without and found important differences in their brains and other body systems.

Researchers showed that a drug used to treat allergic asthma can reduce reactions to peanuts and other common foods in children with multiple food allergies.

A study in India found that children with diarrhea often aren’t given oral rehydration salts because providers assume that parents prefer other treatments.

Gaps around blood vessels that cross the layers of tissues protecting the brain allow certain cells and molecules to move between the brain and the body.

Researchers found that fragments of SARS-CoV-2 left behind after the immune system fights off infection may continue to trigger immune responses.

Scientists identified molecules in blood that may reflect a person’s risk for severe psychotic symptoms and future hospitalizations, and may point to personalized treatment options.

Scientists identified a protein that triggers changes in mitochondria that lead to reduced fat-burning to promote weight gain in mice fed a high-fat diet.